A natural compound extracted (proanthocyanadins) from grape seeds makes laboratory leukemia cells (acidic and damaged white blood cells) biological transform back to their anatomical state, according to a new study by the University of Kentucky. When exposed to the extract, 76 percent of the leukemia cells or acidic cells were dead within 24 hours.
The extract of proanthocycandin forces leukemia or acidic cells to commit "apoptosis," or cell suicide or better said transform, which is a kind of programmed cell death that cells in the body undergo either in the normal course of growth and development or when something goes wrong with them. Leukemia and other acid caused cancers block the cell signaling pathway that allows apoptosis -- this is how cancerous conditions may keep the defenses of the body at bay. Grape seed extract activates a protein called JNK that regulates the apoptotic pathway and allows damaged or acidic cells to commit suicide or biological transform.
Grape seed extract of proanthocycandin has already shown beneficial activity in other laboratory cancerous or acidic cell lines, including breast, skin, lung, and prostate cancers. Before the new study, however, no one had tested the effects of grape seed or proanthocycandin on hematological cancers, and neither had anyone found the exact mechanism involved.
"What everyone seeks is an agent that has an effect on cancer or acidic cells but leaves normal or alkaline cells alone, and this shows that grape seed extract or proanthocycandin fits into this category," said study author Xianglin Shi, Ph.D., who emphasized that research is still in an early stage. Hematological cancers, including leukemia, caused almost 54,000 deaths in 2006, making them the fourth leading cause of cancer death in the United States.
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